Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...

These proteins—and one in particular known as BRD4—are tempting therapeutic targets ... to bind to acetylated histones—proteins that help organize DNA—to act on genes promoting cell ...

While it's well-known that oxygen deprivation changes how cells express DNA, the molecular mechanisms ... and found increased expression of the BRD4-containing CDK9 complex, a multi-protein ...