Northwestern Medicine scientists have uncovered how a testis-specific protein contributes to tumor growth and progression in ...

When BRD4 was removed from cells, BET inhibitors completely killed cancer cells. They also discovered that BRD4 interacts with a protein complex called Mediator, which plays a major role in gene ...

BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.

comprising a hypoxia-activated moiety modified E3 ubiquitin ligase-binding moiety coupled to a protein targeting moiety through a linker reported to be useful for the treatment of cancer.

that are already in clinical trial for cancer therapy. Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, Kriegsheim A Von, et al. Pradeepa MM and FitzPatrick D. BRD4 is mutated in a Cornelia de Lange ...

Genetic CRISPR screening has highlighted that many excellent targets for killing cancer cells are the proteins needed for high-level transcription (ie, BRD4, CBP/p300, MYC). We are designing new ...

PH-894, an INTASYL siRNA compound, selectively silences BRD4, a key regulator of gene expression ... body's immune cells to more effectively kill cancer cells. Phio's lead clinical program ...