BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.

Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...

These proteins—and one in particular known as BRD4—are tempting therapeutic targets, because they use the bromodomain (a stretch of 110 amino acids that give BET proteins their name ...

The study also highlights the complex relationship between BRDT and a related cancer-driving protein, BRD4. While the two share some overlapping functions, BRDT was found to perform certain ...

Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...