These proteins—and one in particular known as BRD4—are tempting therapeutic targets, because they use the bromodomain (a stretch of 110 amino acids that give BET proteins their name ...

Acetylated histones at active enhancers and promoters recruit bromo and extra terminal repeats (BET) protein called BRD4. We recently demonstrated that de novo mutations in BRD4 cause a ...

The candidate, dubbed DC-9476, targets the BRD4 protein, which regulates gene expression by binding to specific marks on histones. By selectively inhibiting the BD2 domain of BRD4, DC-9476 reduces ...