Mutations in BRCA1 and BRCA2 genes render derived tumors selectively sensitive to agents that generate lesions requiring DNA repair by homologous recombination. FANCJ, also known as BACH1 or BRIP1 ...

Mutations in BRCA1 and BRCA2—tumor suppressor genes ... rather than failed DNA repair by homologous recombination, underpins the vulnerability of BRCA-deficient cells to nick-induced damage." ...

Triple-negative breast cancers are often characterized by defects in DNA repair mechanisms involving homologous recombination ... type 1 susceptibility protein (BRCA1). Indeed, mutations in ...

Pharmacogenomics. 2012;13(13):1523-1535. 5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46 ...