The primary job of BRCA2 is to regulate RAD51, a key player in the accurate recombination of DNA during cell division. The researchers found, to their surprise, that when PARP inhibitors ...

The primary job of BRCA2 is to regulate RAD51, a key player in the accurate recombination of DNA during cell division. The researchers found, to their surprise, that when PARP inhibitors ...

A recent study published in Nature has unveiled a previously unknown role for BRCA2 in the context of PARP inhibition. This study demonstrates that PARP inhibitors disrupt a protein called RAD51, ...

Solving a 30-year mystery Boulton became interested in dynamic single-molecule analysis when studying RAD51 — an enzyme regulated by BRCA2 to repair double-strand DNA breaks. Multiple RAD51 ...

5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46] Time of first relapse (years): BRCA ...

These include the ATM and NBS1 proteins that are part of the DSB sensing complex, and the BRCA2 protein that binds to the resected ssDNA (Yang et al., 2002) and catalyzes the formation of the ...

Testing for BRCA mutations linked to breast and ovarian cancers could become easier and more accessible with the help of artificial intelligence, potentially allowing earlier treatment.

Mutations in BRCA2 — a gene known to repair damaged DNA and suppress tumor formation — can predict an individual’s predisposition to develop breast cancer, ovarian, prostate, pancreatic, and other ...