TRKB is the receptor for brain-derived neurotrophic factor (BDNF), and co-expression of TRKB and BDNF promoted further proliferation. The effects of TRKB seemed to be mediated through inhibition ...

When these mice were treated with an artificial peptide that mimicked MDGA2 and inhibited BDNF/TrkB activity, the symptoms lessened. Based on these results combined with previous research ...

In their paper, titled “Mdfa2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice,” research leads Dongdong ...

Research has demonstrated that BDNF binding to a protein known as the TrkB receptor triggers a cascade that promotes the insertion of AMPA receptors into the postsynaptic membrane of silent synapses.

The authors found FRS3 to be a convincing downstream component of the BDNF-TrkB pathway, which could potentially be targeted for obesity treatment. The authors also reference NeuroRestore ACD856 ...

Experiments indicated that a signaling pathway involving BDNF (called the BDNF-TrkB pathway, which helps regulate learning, ...

The Trophin lab focuses on the role of Brain-Derived Neurotrophic Factor (BDNF) and its receptor TRKB in the plasticity and in the mechanisms of drugs used for the treatment of brain disorders. We ...

This is done to evoke neurotrophic or pro-apoptotic signaling. NGF binds to TrkA; BDNF and neurotrophin 4 bind to TrkB; neurotrophin 3 binds to TrkC. BDNF, NGF, and all the receptors are known as ...

His research has focused on the effects of BDNF in neuronal plasticity and on the role of BDNF-TrkB signaling in the antidepressant drug effects. Neurodevelopmental features of the neoplastic brain: ...

When these mice were treated with an artificial peptide that mimicked MDGA2 and inhibited BDNF/TrkB activity, the symptoms lessened. Based on these results combined with previous research ...