Only this time the antigen is whole and B cells don't keep it to themselves. The BCR- and TCR-mediated immunological synapses are strikingly similar in terms of antigen receptor recruitment ...

In the study, "Disease diagnostics using machine learning of B cell and T cell receptor sequences," published in Science, researchers analyzed BCR heavy chain and TCR beta chain sequences from 593 ...

In response to pathogens, vaccines, and other antigenic stimuli, BCR and TCR repertoires undergo changes through clonal expansion, somatic mutation, and selective reshaping of immune cell populations.

Cellecta, Inc. today announced the launch of the DriverMap™ Adaptive Immune Receptor (AIR) TCR and BCR kits, a family of multiplex-PCR, NGS-based assays that enable profiling of up to all seven T-cell ...

Therefore, TCR and BCR sequencing could, in theory, inform disease diagnosis, but this is extremely challenging, owing to technical limitations and the enormous complexity of the data. Zaslavsky ...

Paired BCR and TCR data were available for 542 individuals. Mal-ID correctly classified immune status from blood samples of 542 individuals with both BCR and TCR data. High classification ...