B Cells are a type of lymphocyte whose primary purpose is to generate highly specific antibodies in response to a foreign antigen. The B cell receptor (BCR) signaling pathway regulates B cell ...

However, it is unknown how the self-antigens shape the BCR repertoire of B-1 cells, which may function as templates for the selection of antibody specificities. Nevertheless, regulation of the ...

When a B cell encounters membrane-bound antigen, signalling through the B-cell receptor (BCR) induces cytoskeletal reorganization and morphological changes that lead to the formation of an ...

Only this time the antigen is whole and B cells don't keep it to themselves. The BCR- and TCR-mediated immunological synapses are strikingly similar in terms of antigen receptor recruitment ...

BCR cross-linking by the self-antigens initiates BCR editing, which rearranges the Ig light chain genes to substitute the self-reactive receptors with the non-self-reactive receptors. The B cells ...