Now, there is widespread interest in anticancer agents that trigger the apoptosis of tumour cells, and the BCL-2 family is among the most prominent targets, says David Huang, Principal Research ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the ...

John Seymour, MBBS, FRACP, PhD, explains why BCL-2 was considered an undruggable target for so long and what led to the development of effective BCL-2 inhibitors.