In mammals, certain precursor "mother" cells in the developing hindbrain differentiate into pontine neurons primarily by the action of Atoh1. This gene, discovered by the Zoghbi lab, encodes a ...

Zoghbi and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1 in susceptible brain cells. The team's ...

“We compared the reprogramming efficiency of the hair cell transcription factor ATOH1 alone or in combination with two other hair cell transcription factors, GFI1 and POU4F3, in mouse non-sensory ...

Researchers at Emory University School of Medicine have shown that introducing a gene called Atoh1 into the cochleae of young mice can induce the formation of extra sensory hair cells. Their ...

During this time, these neurons express a transcription factor gene called Atoh1. Using a virus that targets Atoh1, the researchers delivered a specialized receptor, hM3Dq, to only Atoh1 ...