For example, the A allele of rs10423769, approximately 2 Mb upstream from the APOE gene (Rajabli et al., 2022), appears to protect against APOE4 by decreasing its expression (Vance et al., 2024; J.

APOE and TREM2 emerged as key regulators of amyloid ... Targeting CD38 in an AD mouse model restored metabolic fitness, improved cognition, and modified meningeal immunity. Sex and gender ...

APOE and TREM2 emerged as key regulators of amyloid ... Targeting CD38 in an AD mouse model restored metabolic fitness, improved cognition, and modified meningeal immunity. Costa-Verdera et.

The team created a new research model for studying Alzheimer's that involved transplanting human neurons producing the APOE4 ...