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Inflammation-triggering cellular pathway identified as potential new drug target for Alzheimer's diseaseSimilar to the ABCA1 pathway, problems with CPLA2 also lead ... by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD, Molecular Neurodegeneration (2025).
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The second concerning species Prevotella appeared more frequently in individuals carrying the APOE4 gene a known genetic ... The most direct pathway involves bacteria entering the bloodstream ...
It’s possible that the harmful effects of ApoE4 might outweigh the potential ... which includes types of dementia that have pathways that NAIDs may not affect, the authors wrote.
Studies have suggested that APOE4-associated Alzheimer's is a distinct ... they "could see an accelerated approval pathway for this programme, down the road." "In light of the rapid progression ...
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