Figure 6: The mechanism by which WNTs prevent the GSK3-catalysed phosphorylation of axin, APC and β-catenin. Although the use of GSK3 inhibitors to treat diabetes is a potentially exciting ...

Examination of the tumour suppressor adenomatous polyposis coli (APC) has shown that it may be multifunctional. Recent work has demonstrated dynamic interactions of APC with the microtubule ...