Table 1 Selected companies and their antibacterial and antifungal programs ... in the concentration of the drug target—thus eliminating it as a site of action; changes in molecule biosynthesis ...

Another issue is that antifungal drug development takes a long time and ... Over the last 25 years, a compound with a novel mechanism of action has been in development called olorofim.

Danielle is an Assistant Editor at The Scientist. She has a background in neuroscience and molecular psychiatry. She has previously written for BioTechniques News, The Scientist, and Drug Discovery ...

The University of Exeter has launched a new round of funding to tackle the growing global challenge of fungal antimicrobial resistance (fAMR). The FAILSAFE project (Fungal AMR Innovations for ...

"For decades, clinicians have relied on a handful of antifungal classes, with few mechanisms of action and significant limitations due to spectrum of activity, drug toxicities, or drug-drug ...

A groundbreaking cannabinoid-based antimicrobial, Silvanex, fights drug-resistant infections with a synergy of silver, CBC and CBG.

The experience and recommendations of combinational antifungal therapy for ... stated Poorly mimics human disease, the action and side effects of test drug in vivo may not imitate that in human ...

Secondary objectives included assessing the frequency of changes in antifungal therapy due to infusion-related reactions involving amphotericin B formulations, evaluating mycological cure rates in ...

Now, biologists at The University of Manchester have shown that chemicals called azoles - the active agent in many antifungal drugs - kill the TB bacteria, and could be effective in tackling the ...

One thing is certain: The threat of fungal infections is growing, as fungi either evolve ways to evade drugs that once worked, or pop up in places they haven’t been seen before. “We have limited ...

An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic ... used the known mode of action of fluorocytosine on A. fumigatus as the ...

For example, antifungal agents are often ... namely reduction in the concentration of the drug target—thus eliminating it as a site of action; changes in molecule biosynthesis; and pumps that ...