Eribulin is a derivative of halichondrin B with a distinct mechanism of tubulin binding that is in Phase II and III studies in MBC patients. Trastuzumab–MCC-DM1 is a novel agent composed of the ...

The company's unique anti-tubulin payload, XMT-1660, is seen as a potential solution to the issue of topo-1 cross resistance, particularly in TNBC. These are the latest developments in the company ...

Anti-IL1RAP ADC demonstrated potent anti-tumor efficacy and was well tolerated in pre-clinical models Anti-IL1RAP ADC targets ...

Other recent work has identified a viral MP sequence that mimics a tubulin motif and allows the ... showing the zone in which anti-parallel microtubules overlap. The static images of what proteins ...

An anti-IL1RAP ADC was generated from an antibody selected from Cantargia's unique library of IL1RAP-targeting antibodies and conjugated to a tubulin-targeting payload using ImmunoGen (now part of ...