The aberrant expression of partner of NOB1 homolog (PNO1) is known to promote oncogenesis in the colorectum and the esophagus, but its involvement in ovarian cancer and the mechanisms behind it are ...

Activated b-catenin or loss of its negative regulator adenomatous polyposis coli (APC) is a potential biomarker for NT219 in ...

Figure 6: The mechanism by which WNTs prevent the GSK3-catalysed phosphorylation of axin, APC and β-catenin ... dependent protein kinase 1; PKB/AKT, protein kinase B; S6K, ribosomal protein ...

Purple Biotech (PPBT) announced the publication of an independent study titled “IRS2 as a driver of brain metastasis in colorectal cancer: a ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

These proteins interact with critical signaling pathways, such as PI3K/Akt, Wnt/β-catenin, and TGF-β/Smad, influencing cell ...