Fascin is an actin-bundling protein. FSCN1 is recognized as a candidate biomarker for multiple cancer types and as a potential therapeutic target. Now, a new study by researchers at King’s ...

Researchers have described, for the first time, how plastin, an actin-bundling protein, acts as a molecular rivet, providing global connectivity to the cortex underlying the plasma membrane of ...

Indeed, cells without fascin were unable to build nuclear actin bundles to the same extent. Fascin also interacted with another group of important proteins in the cell nucleus, called histones.

Such a dynamic process ultimately leads to the formation of multiple interconnected parallel actin bundles, hence further increasing the mechanical strength of the actin network, says Chen.

The actin-bundling motility protein fascin and vascular endothelial growth factor (VEGF) are universally over-expressed in human angiosarcoma. D. Dim, V. Ravi, J. Tan, D. Hicks, M. Wong Journal of ...

Indeed, cells without fascin were unable to build nuclear actin bundles to the same extent. Fascin also interacted with another group of important proteins in the cell nucleus, called histones. When ...

The actin-related protein (ARP)2/3 complex generates an actin meshwork that operates within a tip-localized, microtubule-depleted zone. The actin meshwork also positions an actin bundle network that ...

Multiple actin filaments (magenta) are organized around a dynamin helical polymer (rainbow colored) in this model derived from cryo-electron tomography. Recent UTSW research shows that by bundling ...

Filopodia are composed of hexagonal bundles of proteins that give them structure and strength. How these intricate bundles come together has been a puzzle for more than 40 years.