In the speculative models suggested so far, formins interact through all their four binding domains with actin, while slow and fast-moving formin would adopt different shapes at the filament.

Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family.

The myosin reaches forward, binds to actin, contracts, releases actin, and then reaches forward again to bind actin in a new cycle. This process is known as myosin-actin cycling. As the myosin S1 ...

These inhibitors aim to halt metastasis by preventing fascin from binding actin filaments and gathering them into bundles within filopodia. Immobilized, the cancer cells are stopped in their tracks.

Actin is one of the most abundant proteins in eukaryotic cells. It exists primarily as monomers (G-actin) bound by G-actin binding proteins that prevent spontaneous nucleation of new actin filaments, ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...