FOXM1 and the ABC transporter ABCC5 were consistently overexpressed in paclitaxel-resistant NPC cells and tumor tissues. We explored whether FOXM1 contributed to paclitaxel resistance by ...

Slow transport via folate receptor (lower affinity for methotrexate than for folic acid) Increased drug efflux via ATP-binding cassette (ABC) subfamily transporters ABCC1–ABCC5 and ABCG2 ...