DNA ligases catalyze the joining of a 5’-phosphate-terminated strand to a 3’-hydroxyl-terminated strand. Ligation depends on magnesium and a high-energy cofactor, either ATP or NAD +. The reaction ...

ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to those of DNA ligases: (Step 1) ligase reacts with ATP to form a covalent ...

Scientists have provided the most detailed account yet of the earliest stages of DNA replication, an essential process for ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

Scientists have finally captured footage of the microscopic machinery that allows our cells to copy DNA—a fundamental process ...

ATP (adenosine triphosphate) is the energy-carrying molecule used in cells because it can release energy very quickly. Energy is released from ATP when the end phosphate is removed. Once ATP has ...