Individuals with mutations in the ATM gene develop ataxia-telangiectasia, a neurodegenrative disorder characterized by immunological defects and cancer predisposition. In an Advanced Online ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Six ATM germline variants were found among the 328 ... to question whether BRCA1 should be considered to be a prostate cancer predisposing gene, given its very low prevalence in the present ...