A research team at the Institute for Basic Science (IBS) has identified a previously unknown enzyme, SIRT2, that plays a key role in memory loss associated with Alzheimer's disease (AD).

Kazantsev and colleagues, writing in Science, have shown that inhibitors of sirtuin 2 (SIRT2) — a member of the histone deacetylase family of enzymes — rescues α-synuclein-mediated toxicity ...

After a series of processes, they managed to isolate two enzymes considered key in this action that are SIRT2 and ALDH1A1. The first was detected at very high levels in both mice and humans after ...