Mutations in the PS1 gene are responsible for the most aggressive form of AD and account for 18-50% of all early-onset AD cases. [4] PS1 mutations are mainly missense substitutions that are ...

and decreased astrocyte-driven neuroinflammation in the APP/PS1 mouse model of Alzheimer's. Acute treatment also reduced brain interstitial fluid Aβ40 levels by approximately 15% within 20 hours.