Deficiency of ADAMTS13 plays a critical role in platelet accumulation in PA-ILI, suggesting that ADAMTS13 could be a potential therapeutic target for this condition.

congenital TTP (cTTP), caused by mutations in the ADAMTS13 gene, and immune-mediated TTP (iTTP), caused by an autoimmune response to ADAMTS13. People with TTP can sometimes live for years without ...