MGTX uses AAV5 capsid vectors and riboswitch technology to deliver gene therapies, aiming for safer and more controlled treatments compared to earlier approaches. Financially, MGTX has a strong ...

1). In contrast, AAV5, a capsid used in other HD therapies, transduces neurons only where it is injected, using a method for delivering larger volumes of material into the brain. AAV-DB-3’s ...

More recently, capsid evolution screens have yielded additional proprietary candidates, derived from AAV9 or AAV5, which demonstrate enhanced brain transduction relative to their parental ...

All other critical quality attributes of AMT-061 are expected to be comparable to those of AMT-060, as AMT-061 utilizes the same AAV5 capsid and proprietary insect cell-based manufacturing platform.

All other critical quality attributes of AMT-061 are expected to be comparable to those of AMT-060, as AMT-061 utilizes the same AAV5 capsid and proprietary insect cell-based manufacturing platform.

Agreement grants Lilly rights to employ Sangamo’s novel proprietary capsid, STAC-BBB, for up to five potential disease targets Sangamo to receive an $18 million upfront license fee and is ...