Much of these challenges are a function of the physical complexity of an AAV virion and the cell line-based manufacturing systems. An aspirin molecule is composed of 21 atoms. A standard ...

For central nervous system (CNS) applications, attempts are being made to deliver AAV gene therapy directly to the brain parenchyma or the cerebrospinal fluid (CSF) space by intra-cisterna magna ...

Rituximab may be an effective therapeutic option in the management of severe necrotizing scleritis associated with AAV. A middle-aged man was diagnosed with necrotizing scleritis associated with ...

Safe and effective gene therapy strategies depend on robust and reliable adeno-associated virus (AAV) mediated therapeutic gene delivery. However, scaling up AAV manufacturing to obtain sufficient ...

This in silico approach aims to increase the fitness of clinical adeno-associated virus (AAV) capsids to make gene therapies more economically viable for patients. Developing AAV capsids with ...

To assist researchers in the selection of the optimal AAV vector for their application, we have generated a detailed map of viral delivery to tissues in mice, the most commonly used experimental ...

That deal is worth $35 million per year in average annual salary, but he reportedly could have gotten an even bigger deal in AAV from the Baltimore Orioles. Roch Kubatko of MASN reported that the ...

An analysis of data on patients with AAV who underwent TPE found low short-term complication rates but an increased risk of serious infections. “The removal of autoantibodies and immune ...

Coave's proprietary ALIGATER platform enables specific retargeting of AAV vectors to human receptors via a one-step chemical conjugation of peptide-based ligands at the surface of the capsid, ...

Developing AAV capsids with improved yield, or fitness, is a key strategy for reducing manufacturing costs in order to make gene therapies more affordable. Christian Mueller and coauthors from ...