(3) Researchers inject the AAV mixture into a living model, such as a mouse. The different AAV will transduce, or infect, the animals’ tissues. (4) Scientists collect the tissues of interest and ...

A 1984 paper by Paul Hermonat and Nicholas Muzyczka offered the first demonstration that AAV might provide a safe and effective vehicle for transgene delivery, with helper adenovirus infection ...

Rituximab may be an effective therapeutic option in the management of severe necrotizing scleritis associated with AAV.

Next, they loaded this base editing tool onto AAV-Sia6e, which has high infection tropism for inner ear cells and developed an all-in-one AAV vector for inner ear genome editing. Genome editing ...

Although infection is often considered first in febrile, cytopenic patients, this report illustrates the need for vigilance regarding AAV and hemophagocytic lymphohistiocytosis when conventional ...

Infection in humans with wild-type AAVs is prevalent, with prior exposure to AAV, shown in 30–80% of individuals, based on AAV serotype, patient age, geographical location and several other ...

Adeno-associated virus (AAV) gene therapies hold great promise, but ensuring product quality is critical. One major challenge? The presence of empty capsids, which can reduce therapeutic effectiveness ...

Gene therapy represents one of the fastest growing biotherapeutics worldwide, with AAV at the forefront. This rapid growth is constantly challenging CMC approaches, from manufacturing through release ...