(B) Confocal microscopic images of coronal brain sections of the amygdala of wild type mice, showing the EGFP fluorescence ... of endogenous CaMKIIα. Single AAV Systems for HDR-Mediated Genome ...

Adeno-associated virus (AAV) gene therapies hold great promise, but ensuring product quality is critical. One major challenge? The presence of empty capsids, which can reduce therapeutic effectiveness ...

Developing AAV capsids with improved yield, or fitness, is a key strategy for reducing manufacturing costs in order to make gene therapies more affordable. Christian Mueller and coauthors from ...

Newcells' retinal models have been validated for screening and selecting the most effective adeno-associated viral (AAV) vectors with enhanced photoreceptor targeting for retinal gene therapy.

Coave's proprietary ALIGATER platform enables specific retargeting of AAV vectors to human receptors via a one-step chemical conjugation of peptide-based ligands at the surface of the capsid, ...