Siren said proceeds will go toward investigational new drug (IND)-enabling animal studies and clinical-grade production of ...

So far, brain regeneration in the axolotl has been ... By testing different AAV serotypes—variants that target different cell ...

This in silico approach aims to increase the fitness of clinical adeno-associated virus (AAV) capsids to make gene therapies more economically viable for patients. Developing AAV capsids with ...

To assist researchers in the selection of the optimal AAV vector for their application, we have generated a detailed map of viral delivery to tissues in mice, the most commonly used experimental ...

This gene plays a crucial role in the brain's ability to regulate activity ... Solving the puzzle of gene size limits: Gene ...

Gene therapy represents one of the fastest growing biotherapeutics worldwide, with AAV at the forefront. This rapid growth is constantly challenging CMC approaches, from manufacturing through release ...

Developing AAV capsids with improved yield, or fitness, is a key strategy for reducing manufacturing costs in order to make gene therapies more affordable. Christian Mueller and coauthors from ...