Understanding the intricate mechanisms of gene regulation is crucial for unraveling the complexities of cellular function and disease. Recent discoveries highlight a profound interplay between DNA and ...

Company licenses novel deep learning-based epigenetic models from CUHK enabling the detection of 5hmC, 5mC hemimethylation, and 6mA in standard sequencing runsMENLO PARK, Calif., April 28, 2025 (GLOBE ...

Scientists have determined that alterations to DNA methylation patterns, including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) residues, can serve as early indicators of diseases such as ...

3 Cytosine methylation occurs when a methyl group binds to the fifth carbon of a cytosine to form 5-methylcytosine (5mC). Researchers cannot detect 5mC with traditional molecular techniques such as ...

This new technology aims to improve the detection of DNA modifications, including 5-hydroxymethylcytosine (5hmC) and hemimethylated 5-methylcytosine (5mC), and will be incorporated into PacBio's ...

PacBio plans to bring these capabilities to its Revio and Vega systems, building on its existing 5mC support to deliver even more comprehensive epigenomic insights as part of standard HiFi whole ...