A new study on mice reveals that the brain’s response to rewards is temporarily suppressed after the first dose of citalopram ...

According to the partners, DSP-0038 combines serotonin 5-HT2A receptor antagonism and 5-HT1A receptor agonism – two well established targets for antipsychotic drugs – in a single small molecule.

According to Johns Hopkins Medicine, roughly 9.5 percent of American adults ages 18 and over will suffer from a depressive illness (major depression, bipolar disorder, or dysthymia) each year.

In these women, sublingual testosterone can increase sensitivity to sexual stimuli, and a subsequent dose of a 5-HT1A-receptor agonist then inhibits the sexual-inhibition mechanism. On the basis ...

The drug is a long-acting and potent serotonin 5-HT1A receptor agonist and will be added to DSP’s psychiatry and neurology research pipeline. Paul Workman, chief executive of The Institute of ...

trace amine-associated receptor 1 agonist, and 5-HT1A agonist indicated for the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea; and Symbravo ...

In a follow-up study, Muñoz et al. investigated the effect of 5-HT-receptor blockade in macaque and rat models of PD with L-DOPA-induced dyskinesia. The authors then tested prolonged ...

Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL (2007). R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett 17:4128-4130.