PsyPost on MSN1mon
How SSRIs affect serotonin receptors: New findings from a depression study
However, 5-HT4 receptor binding activity decreased by 9% ... that is consistent with increases in synaptic extracellular 5-HT ...
Medscape3mon
Role of the Serotonin Transporter in Pulmonary Arterial Hypertension
Emerging evidence suggests that the SERT and the 5-hydroxytryptamine (5-HT) 1B receptor cooperate in mediation of serotonin-induced pulmonary vasoconstriction and remodeling. Dexfenfluramine (a ...
Nature5y
Reduction of L-DOPA-induced dyskinesia in animal models of Parkinson disease
In a follow-up study, Muñoz et al. investigated the effect of 5-HT-receptor blockade in macaque and rat models of PD with L-DOPA-induced dyskinesia. The authors then tested prolonged ...
Medscape2mon
Insights Into the Pharmacological Targeting of the Trigeminocervical Complex in the Context of Treatments of Migraine
The development of the anti-migraine therapeutics, triptans-5-HT 1B/1D receptor agonists, had originally targeted the craniovasculature to exert therapeutic effects, and this locus of action ...