They found no cognitive effects (no harm nor any benefit) based on whether women were exposed to 48 months of hormone therapy or a placebo. It appears the effects of menopause hormone therapy on ...

Women in North America tend to experience menopause between 51 and 52 years old, while the global average is closer to 48.

given for 12 months produced only a small increase in the risk of disease flares (0.64 probability in HRT patients vs 0.51 in placebo controls, with most flares mild or moderate [p = 0.01]).