Tumor necrosis factor ligand superfamily member 9 (4-1BBL), also known as 4-1BB ligand, CD137L, or TNFSF9, is a cytokine that binds to TNFRSF9. It serves as the high-affinity ligand for 4-1BB and ...

which triggers 4-1BB signaling to stimulate NK cell proliferation and IFN-γ secretion. 4-1BBL is often co-administered with other cytokines to enhance the activation of NK cells. 3. Augment DC antigen ...

For example, one program is developing a BsAb with binding sites for tumor-associated antigen (TAA) and 4-1BB (also known as CD137), an inducible costimulatory molecule found on a number of cell ...

Eutilex’s CEO, Byoung S. Kwon, is a leading immuno-oncology researcher responsible for the discovery of the human 4-1BB, an inducible costimu-latory receptor expressed on activated T cells.