The most common doses of Seroquel used in clinical sleep trials ranged from 25 mg to 300 mg once daily before bed. Some clinical trials recommend a starting dosage range from 50 mg to 150 mg per day.

Quetiapine XR was administered at 300 mg on day 1, 600 mg on day 2 and up to 800 mg after day 2. From day 8 until the end of the study, the dose of quetiapine XR was adjusted within 400-800 mg per ...