HSP90 is also a mediator of cellular homeostasis ... that experimental prostate cancer growth in bone is enhanced by 17-AAG as a consequence of localized transient activation of SRC signalling ...

and there was concern that when the HSP90 inhibitor 17-AAG entered Phase I clinical trials, unacceptably toxic effects would be seen. However, 17-AAG seems to be well tolerated, and now Adeela ...