Saint-Priest is a commune in the Metropolis of Lyon in the Auvergne-Rhône-Alpes region in eastern France. It is the fourth-largest suburb …Saint-Priest is a commune in the Metropolis of Lyon in the Auvergne-Rhône-Alpes region in eastern France. It is the fourth-largest suburb of the city of Lyon, and is located to its southeast side. The Saint-Priest station is served by local trains to Lyon and Saint-André-le-Gaz.