Cambridge is a city in Guernsey County, Ohio, United States, and its county seat. The population was 10,089 at the 2020 census. It lies in the Appalachian Plateau of the Appalachian Mountains in southeastern Ohio, about 75 miles east of Columbus and 124 miles south of Cleveland. It is the principal city of the Cambridge micropolitan area and is located adjacent to the intersection of Interstates 70 and 77.
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