ob/ob mouse - Wikipedia
WEBThe ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes.
A Mouse Model of Diet-Induced Obesity and Insulin Resistance
WEBThe mouse model of diet-induced obesity has become one of the most important tools for understanding the interplay of high-fat Western diets and the development of obesity.
C57BL/6J substrain differences in response to high-fat diet ...
WEBAug 20, 2020 · C57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift and...
Diet-induced obesity in animal models: points to consider and …
WEBMar 18, 2021 · Experimental animals. The animal species most commonly used for obesity induction through diet is mouse, with isogenic or inbred strains, such as C57BL/6, C57BL/6J, AKR/J, and A/J [7]. In the present study, most of the analyzed studies used C57BL/6J mice (Table 2).
A systematic review on different models of inducing obesity in …
WEBDec 14, 2019 · The studies have revealed that mice can attain a weight three times more than unaffected mice. It was found that the obese mice had enlargement of the pancreas and increased production of insulin, leading to hypercorticosteronemia, insulin resistance, hyperglycemia, hyperinsulinemia, and hypothyroidism as well as infertility .
Effects of different diets used in diet-induced obesity models on ...
WEBDec 20, 2019 · When fed ad libitum with a high-fat diet (HFD), obesity, hyperinsulinemia, hyperglycemia and hypertension establish in these mice. Control groups fed ad libitum with normal chow however, do not...
Novel insights into the genetically obese (ob/ob) and diabetic …
WEBJun 28, 2021 · Ob/ob mice are characterized by a mutation of the obese (ob) gene encoding leptin, whereas the db/db mice have a mutation of the diabetes (db) gene encoding for the ObR .
Optimal fasting duration for mice as assessed by metabolic status
WEB6 days ago · Mouse model. High-fat diet. In the study of obesity and diabetes, mice are widely used for experimental research, and fasting is a common procedure used to reset metabolism in mouse models. The ...
Sex differences in a mouse model of diet-induced obesity: the …
WEBJan 10, 2024 · Previous studies of diet-induced obesity utilizing mouse models have demonstrated a difference in bodyweight gain by sex. In such studies, female mice gained significantly less weight than male mice when given the same high fat (HF) diet, indicating a resistance to diet-induced obesity.
New research uncovers a path to lowering obesity in mice by …
WEBJan 17, 2022 · Blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice, according to new research led by the University of Michigan Life Sciences Institute.